This mechanism allows scalability, avoiding the manipulation of a huge number of products.
Perhaps one strategy to leverage our knowledge of interaction networks into efficacious therapies would be to identify and exploit weak or fragile mechanisms while avoiding the manipulation of robust network interactions.
Using a cell proliferation assay, which avoids the manipulation of the treated cells, our results indicated a greater radiosensitivity for the AT heterozygote cells as a group, compared with the normal cells.
7– 15 MCRs proceed with remarkably high atom and step economy by reducing the number of functional group manipulations, thus avoiding the use of protective groups and, as such, are ideally suited for the generation and validation of catalyst libraries.
"A lot of people are leery of the face-to-face interaction with the dealer's sales staff, so not taking a test drive allows them to avoid all the manipulation and game-playing".
"Surprisingly, consumers of alternative news, which are the users trying to avoid the mainstream media 'mass-manipulation,' are the most responsive to the injection of false claims," Quattrociocchi wrote.
This way we avoided the usual manipulations related to microinjection, and minimized extraneous disturbances to the rat.
Encouraging results using the Sterile Insect Technique highlighted some metabolism manipulation to avoid the viability of offspring from released parent insect in the wild.
A strategy to compromise the favorable aspects and to avoid the unfavorable effect during OsBADH2 manipulation and breeding is discussed as well.
mTOR-independent autophagy is perhaps a more interesting target for drug discovery, as targeting this pathway may avoid the pleiotropic consequences of mTOR manipulation in a disease context.
