The phrase "avoid breakpoints" is correct and usable in written English.
It can be used in contexts related to programming or debugging, where one might want to prevent the execution of code from stopping at certain points.
Example: "To ensure a smooth execution of the program, please avoid breakpoints during the testing phase."
Alternatives: "prevent breakpoints" or "steer clear of breakpoints".
The low odds ratios near genes are likely due to the fact that ETSwt/CHD1del prostate cancers avoid breakpoints near genes while many protein binding sites are fixed near gene promoters.
To avoid breakpoints at outlier values, for each amplicon i, we give the segmentation algorithm weightings w, which are inversely proportional to the variances σ i 2. Generally, all NRC values within a segment resulting from the CBS correspond to a particular copy number status.
Breakpoints in rat and dog were excluded from this analysis in order to avoid consideration of breakpoints that could have been identical-by-descent and shared either by mouse and rat or by dog and cow.
This result agrees with our previous observation that most breakpoints avoid non-coding conserved regions and is consistent with previous studies stating that most gene deserts are not broken by evolutionary breakpoints [ 18].
To avoid consideration of breakpoints that did not result from independent breakage (and which could have been identical-by-descent), we selected only breakpoints that were present in mouse, cow, opossum and chicken, respectively.
Within these gene sets, breakpoints significantly avoid the domain-encoding regions (domons), except where these regions constitute most of the sequence length.
To avoid treatment failures, using microbiologic breakpoints for quinolone susceptibility would be more prudent than using clinical breakpoints.
In order to avoid double counting of some breakpoints, we repeated the simulations, this time considering only the breakpoint regions in mouse (N = 132), cow (N = 143) and opossum (N = 89).
Therefore, recombination breakpoints that fall within a domon show little or no tendency to localize away from its center, i.e. recombination breakpoints do not avoid disrupting core protein-domain structure, and under this test we find no compelling evidence to reject our third null hypothesis.
The translocation-related human proteins are enriched in disorder (43.3% versus 20.7% in all human proteins) and their translocation breakpoints tend to avoid domain splitting.
Thus, in addition to activating DNA damage signaling, ATM modulates the loading of recombinational repair proteins onto translocation breakpoint hotspots to avoid inappropriate recombination leading to chromosome translocation.
