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SirT3 expression prior to p53 induction was required to completely avert growth arrest in the EJ-p53 cells (Fig. 3D).
Therefore, our results suggest that SirT3 expression can avert growth arrest by p53, however, the extension in cellular lifespan is temporary and can not immortalize the cells like MSCV-GFP/c-myc (Fig. 3B).
To determine further whether SirT3 has the capacity to avert growth arrest and to extend cell longevity we evaluated the role of SirT3 to increase the replicative potential of EJ-p53 cells.
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We explore a fracture mechanics approach to formulate design rules to avert crack growth.
Originally, the registration system was part of Communist social planning and helped China avert the growth of huge urban slums.
Bush administration officials said the figures buttressed their case that Congress, and Democrats in particular, had to do more to keep spending on nondefense programs in check to avert uncontrolled growth in the deficit.
With this aim, we performed a functional screen for cDNAs that could avert the growth arrest phenotype in the EJ –p53 inducible cell model.
It also highlights the need for prenatal and early life interventions to avert the growth failure that occurs during this sensitive period and decrease the risk of maternal mortality and disability due to obstructed labour.
Similar to Hosie and colleagues [ 117] who argued for reforms to the mental health system to avert unsustainable growth in demand for treatment, we believe there are multiple opportunities from before birth into early adulthood to reduce people's risk of developing mental illness.
Although no study is available to confirm this hypothesis, if it held true, the more balanced combined strategy used in our study might avert concerns about growth.
However, a quick tour through the gigantic loopholes of the act -- already exploited by Carter to avert the cost growth and schedule delays found by the JET for the F-35 -- informs any but the most clueless that the cost the Air Force and Navy predict today to shrink and age their own air forces is woefully understated.
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Justyna Jupowicz-Kozak
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