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Regardless, the higher P/L ratio available when using DDGly resulted in equivalent signal-to-noise with half of the signal averaging compared to that of the SDS sample.
Available data thus show that the higher probability of not selecting a redundant variable in Bayesian model averaging compared to stepwise regression does not come at the price of lower probability of selecting a true predictor but instead provides us with similar probability of selecting a true predictor as stepwise regression.
The nonequivalent Ile, Thr, and Val residues of hDHFR show an enhanced degree of rotameric averaging compared to that of the residues of ecDHFR, with an average pmajor of 0.68 ± 0.18 in hDHFR versus a value of 0.90 ± 0.07 in ecDHFR for the E FOL NADP+ complex (see Figure S6 of the Supporting Information for histograms of the pmajor distributions for hDHFR and ecDHFR E FOL NADP+ complexes).
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