A population average of baseline scans blood data was constructed using leave-one-out cross-validation for each scan and used in conjunction with individual blood samples.
Hour-by-hour values for the first 8 h and daily averages up to the fifth day were compared with the average of baseline values by analysis of variance.
After this transformation, for Experiment 1 and Experiment 3, ratios between the averages in the different conditions and the average of baseline were computed.
Raw values (Ft) were normalized to the average of baseline calculated before NMDA application (Fr) and data were plotted as ΔF/F = (Ft−Fr)/Fr.
We also calculated grand-averages of baseline identity MMN responses and calculated the mean amplitudes across a 40-ms window centered at the peak latency at FCz.
For example, at 1 year the updated mean is the average of the baseline and 1-year values and at 3 years it is the average of baseline, 1-year, 2-year, and 3-year values.
For example, at 2 years the updated mean of SBP is the average of baseline, 1-year, and 2-year values.
For example, at 1-year follow-up, the updated mean was the average of the baseline and 1-year values, and at 3-year follow-up, the updated mean was the average of baseline, 1-year, 2-year, and 3-year values.
Similar results were found for all three exposure measures based on an average of baseline and follow-up questionnaire data including suggestion of an exposure-response relationship for cold tap and total tap water intake.
Sensitivity analyses included a single imputation method for missing GHb follow-up measures using the baseline GHb observation carried forward, an average of baseline GHb among all participants carried forward, and an average of all available post GHb by study group.
The average of baseline steps in the intervention group was 3,249, by considering 10,000 as a final target; participants in the intervention group were advised to increase their steps by 500 per week [ 21] until they reached the first target of 5000 steps per day [ 22].
