To calculate, e.g., the average trough concentrations for a set of doses at trough time (evaltime), 3*24 = 72 h, we calculate the statistic of interest, concstat, at each integration step, but we only store it into stats if we have arrived at the time of evaluation.
No patient had a high trough infliximab concentration, 17 patients (71%) had medium trough concentrations, and 7 (29%) had low trough concentrations.
Mean trough concentrations after the second ziv-aflibercept dose plateaued and remained at ∼10 mg l−1.
Mean trough concentrations of linagliptin were similar across visits (ranging from ∼7 to 10 nmol/L).
To determine the incidence of vancomycin-associated nephrotoxicity in children and to examine potential risk factors for nephrotoxicity, including average serum trough concentrations ≥15 mg/L.
70 The average trough plasma rilpivirine concentration was 52 ng/mL two weeks after switching therapy.
70 For weeks 4 12, the average trough plasma rilpivirine concentration was 66 84 ng/mL.
To investigate the reduction of drug exposure due to ADA emergence, cutoff values for adalimumab trough concentration were chosen at 1/2, 1/5, 1/10, 1/20, and 1/50 of the average drug concentration in patients who carry no binding pairs (and thus do not develop ADA).
The infliximab concentration used in this study is within the therapeutic range for RA and is close to the average trough level of 3.3 μg/mL [ 19, 20].
