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White matter (average t score 2.7 and P = 0.03) and the thalamus (average t score 2.6 and P = 0.06) exhibited the highest fraction of voxels with P < 0.01 (> 55%).
The fraction with P < 0.01 was below 25% in the frontal lobe, temporal lobe, and in cerebellar grey matter (average t score < 1.8 and P > 0.10).
We found that the largest average T score values of gray matter decrease were found in temporal and occipital lobes in the group of people with AN.
We present no average T score showing gray matter increase (only 1 study reported increase in the right DLPFC, Brooks et al., 2011).
We used frequency data to examine both average T score intensity (to represent size of difference between case vs. control brain volume) and absolute number of studies reporting on specific brain regions, by aggregating T-statistics, generalising to a specific lobe of the brain (including mid-brain) and calculating an average score.
In the second ALE meta-analysis, representing the regional gray matter volume decrease in those with AN (there was only 1 study reporting gray matter increase), 7 studies were included, with a total 102 patients and 120 controls; In the third analysis, we examined average T score intensity and 5 studies were included.
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The results suggest that their average T scores were within 1 SD of the mean of the normal-hearing normative sample (i.e., 50 ± 10, as provided by the test developer).
Results for the neurocognitive measures were below average (T- score: mean 50; SD = 10).
However, the average t-score for institution B was the second highest among all institutions.
The average T-score was much lower in hip fracture patients than that in controls, -2.58?±?1.06 vs. -1.85?±?1.3.
An average T-score of −1.23 was reported and the prevalence of OP was 8.79 % in our study sample.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com