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Consequently, we decided to take the average of these repeated values instead of the median value: this latter value would be more suitable only if outliers were more aboundant.
Our simulation results indicate substantial gain in power using LGRF when compared with two commonly used existing alternatives: (i) single marker tests using longitudinal outcome and (ii) existing gene-based tests using the average value of repeated measurements as the outcome.
Furthermore, "bad spots" that had signal values deviated more than 50% of average values of repeating spots and/or spot CV larger than 0.5 were discarded.
During data process, "bad spots" that have signal values deviated more than 50% of average values of repeating spots and/or spot CV larger than 0.5 are discarded.
The miRNA microarray data used the total gene signal, which was the average value of repeating spots.
= average of the repeated χ2 statistics.
Approximately 1 hour later, the measurement was repeated and the average of two values was taken as the baseline thermal nociceptive threshold.
We sample the short-term fairness horizon 50 times by repeating this procedure and take the average of these values.
The average of these values is denoted as d 0. The same procedure was repeated 100,000 times to obtain d i, 0 i = 1,..., 100,000.
By repeating the above procedure k times, we used the average of k values for discrimination rate to estimate the accuracy of the model.
Average and standard deviation values were calculated based on the results of repeated triplicate experiments.
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