Sentence examples for average mutation frequency from inspiring English sources

Control experiments through subcloning and sequencing confirmed that only the vector backbones were mutated with an average mutation frequency of ~1.25 mutations per kb.

Since the mutator lesions become progressively enriched with increasing progress towards malignancy, any experimental technique which looks at average mutation frequency across many premalignant lesions might falsely conclude that a mutator mutation is a "late event".

It is likely that the mutational load has to be optimized depending on the vector size; an average mutation frequency of 1.25 mutations per 1 kb prove to be efficient to increase enzyme production and all three sequenced vector backbones contained five to six mutations.

We identified 3,726 point mutations and more than 90 indels in the coding sequence, with an average mutation frequency more than 10-fold higher in smokers than in never-smokers.

An average mutation frequency of 1.00-1.25 mutations per 1 kb plasmid DNA was obtained (Additional file 1: Figure S2) and all inserts did not contain a mutation.

The average mutation frequency was 1.2 × 10−3 (Table 1).

Despite this, the average mutation frequencies for the four targets were almost identical.

(A ) The average mutation frequencies in the exons of 13 MMR-deficient tumors and four MMR-proficient tumors.

In such clones extinction was not achieved despite the genomes reaching average mutation frequencies which are 5- to 37-fold higher than those associated with viral extinction by lethal mutagenesis [ 32, 39, 41, 48].

Indeed if hypermutation were occurring throughout the genome at the same frequency observed for the dms4-1 gene, then we should have detected ∼53,000 mutations in each suppressor mutant [average mutation frequency of dms4-1 suppressor mutations (1.2 × 10−3; Table 1) times 4.4 × 10, which is the number of base pairs susceptible to EMS mutagenesis in Arabidopsis (Jander et al. 2003)].

The frequency of an A6 → A7 reversion was estimated as approx. 1,000 fold higher than the estimated average point mutation frequency (i.e., 4.5 × 10-10 [ 29]).