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Average time from last dose of preoperative chemotherapy to surgery was 50 ± 34 d.
1: b.i.d.: twice daily; q.d.: once daily 2: Unless otherwise stated, average time from last dose celecoxib to blood draw 3: The text did not define how many weeks the subjects took the medication In three of the groups of women (premenopausal @ 200 mg bid, postmenopausal @ 200 mg bid and premenopausal @ 400 mg bid), plasma celecoxib concentrations ranged between 195 and 267 ng/ml.
The average follow-up time from the start of treatment until the second biopsy was 12 weeks, and the average time from the last dose of cisplatin to the second biopsy was 4 weeks.
Average time to collection after last dose was similar for both the premenopausal and postmenopausal subjects.
Thus, blood for serum levels measurements were collected on average 12 or 24 h after last dose according to standard laboratory requirements.
In a third of the patients, no decision was taken to stop chemotherapy despite the last dose being an average of just 1 week before death.
Patients undergoing chemotherapy received a mean 7.4 cycles and waited an average of 10.6 weeks after their last dose of chemotherapy before proceeding to surgery.
All women had NAF and plasma collected within 24 hrs of their last dose of celecoxib, with an average of approximately 12 hrs.
The last dose was defined as the recorded dose of the last administration (infliximab and abatacept) or average daily dose for the last prescription fill (etanercept and adalimumab).
The median exposure to lenalidomide was calculated as the average dose over all the days between the first and last dose date, including the 7 d off-drug in each 28-d cycle and any interruption periods.
In mice treated with 50 mg/kg ibuprofen daily for 3 days and reported to demonstrate GSM activity, the average plasma drug concentration was 43 μM, 2 h after the last dose [ 51].
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