An interesting consequence of independent pathway competition is that fairly small changes in kinetics of either pathway can cause large changes in average cell fate.
Large variation in average cell fate despite relatively small variation in pathway may explain why the cell death response to anti-mitotic drugs varies strongly across cancer cell lines [6], and why individual cells within a line can exhibit different fates.
ALTHOUGH Europe may seem far away from the economic life of the average American, the fate of the euro zone weighs heavily on the United States economy.
By the law of averages, Keen Ice's fate in the Belmont Stakes looks none too promising.
The average values of each fate (from 10 different lattices) in each of the two simulations are shown in Tables 2, 3.
With a lower dose of 4OH-tamoxifen, label was introduced into GFRα1+ cells sparsely (one labeled unit per ∼6 mm tubule length on average), so that the fate of each "clone" (defined as a cohort of cells derived from a single labeled unit, regardless of whether or not they have split into multiple units) can be analyzed.
Despite the apparent variability in the individual clonal fates, the average of more than 100 clones at each time point recovered a conventional steady-state stem cell behavior through this period: in particular, the average number of GFRα1+ units per clone remained close to one, whereas the number of GFRα1− units (and, more dramatically, GFRα1− cells) per clone steadily increased.
Those that avoid this fate have, on average, a debt-to-equity ratio of less than 1.5.
For example, genes involved in protein synthesis and protein fate showed higher average GEI in stationary phase 10403S as compared to genes involved in other functions, while genes involved in viral functions and amino acid biosynthesis were significantly associated with low average GEI in 10403S.
Terminator: Salvation, Transformers 2: Revenge of the Fallen, Watchmen: The End is Nigh and Wanted: Weapons of Fate have all averaged scores in the 50s and 60s out of a potential 100, so it is clear not all developers are creating high-quality releases.
