To calculate the value of the parameter α we required an estimate of the initial average body fat mass which was not directly measured in NHANES.
Importantly, the average fat to lean mass ratio was significantly reduced in male and slightly reduced in female heterozygous mutants when compared to wild-type animals (Figure 1F).
Again, this effectively only asks if the treatment is significant at the average lean and fat mass – i.e. at the central point of each plane.
This effectively only asks if the treatment is significant at the average lean and fat mass – i.e. at the central point of each plane indicated by blue and red dots in Fig. 7.
A recent RCT by Monninkhof et al. [ 20] did not find a significant effect of exercise on SHBG change over 12 months, possibly because the average decrease in fat mass among exercisers (0.8 kg) was lower than in our study (2.4 kg; ref [ 8]).
129.Dll1tm1Gos/+ animals showed a significantly reduced average body fat content (Figure 1C), reduced average fat-free dry mass (Figure 1D) and a reduced average lean-body mass (Figure 1E) when compared to wild-type littermates.
On the other hand, at the age of 16 weeks, female FtoΔ/Δ mice had even more fat mass on average than their wildtype and heterozygous littermates (Figure 4B), while their lean mass were still less than the controls (about 12% less, not as dramatic as the difference in males) (Figure 4A).
Results for the LP one repetition maximum, SPPB, 400-m, total lean and fat mass, BMI, average dietary protein and fiber intake in older adults (mean age, 77.7 ± 3.9 years; N = 73, 43 women, 30 men) from the randomized, double-blind, controlled study of (Chale et al., 2012) were used.
