Sentence examples for average expression profile from inspiring English sources
We formalized eight models to represent the average expression profile of these genes: Up-early, in which genes were expressed to their maximum level within the first 6 hrs; Up-linear, in which genes continually increased over the time-course; and Up-late, in which genes stayed constant till the 24 hr time-point.
We identified 3882 differentially expressed (DE) mRNAs; an mRNA was considered to be DE if the average expression profile of healthy donors was different from that of patients in one or more categories.
The four controls were treated as replicates and the average expression profile for each subtraction of the control data was calculated.
As an alternative approach to identify genes induced during the early stage of infection that could be associated with clearance, the average expression profile of persistently infected chimpanzees (X0234 and X0140) was compared to the average expression profile of chimp X0190 during weeks 4 and 6.
We have also shown if an average expression profile of some state of interest can be properly defined (i.e. distant metastasis) then the Jensen-Shannon Divergence can help us to identify which probes best correlate with these measures resulting in useful biomarkers.
Since there is a higher than 95% chance that cluster assignments are accurate (Supplemental File S2), and our validation analysis shows that 90.7% of the array expression patterns match the RNA analysis results using other techniques (e.g., Q-PCR), we estimate that more than 86% of the genes in a cluster follow the corresponding average expression profile.
Note that, the average expression profiles for all probe-sets have been taken for genes that are represented by more than one corresponding probe-set.
This timeline is confirmed by the data presented, implicating that most expression profiles return to baseline at 56 days, as shown by the average expression profiles (Figure 3).
The graphical representations of the average expression profiles for each of the 8 unique temporal clusters determined by cluster analysis of significant gene probe sets are shown in Figure 3.
The major biological processes identified exclusively for increased gene expressions, which all peaked between days 5 and 10 as shown by their average expression profiles (Figure 4A), consisted of a large variety of processes related to neurogenesis, skeletogenesis, cell motility, cell adhesion, vasculogenesis, and Wnt signaling, as supported by detailed information in Tables S2A and S2B.
