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A negative correlation between pre-ablation tumor volume and D50, average dose, and V100 was identified (ρ < − 0.5, P < 0.05) suggesting that adjuvant radiofrequency ablation may be less beneficial to patients with large tumor burdens.
This was based on market share of the different drugs available, average dose and prices.
However, a rough comparison based on the average dose and peak instantaneous irradiance can be made.
Continuous variables (age, average dose and duration) were categorised into quintiles.
The average dose and total amount of ISMN exposure were nonetheless not associated with the likelihood of developing MACEs.
Although we were not able to measure GTP-bound active Ras (RasGTP) by flow cytometry, the population average dose and dynamic responses were assayed via pull-down and Western blotting, and then quantified.
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Some people need higher-than-average doses; some, being very sensitive to drugs, cannot tolerate even average doses, and they experience side effects when others do not.
The CVs were 0.29 (normal) and 0.42 (tumour) for Pt 1 and 0.77 (normal) and 0.089 (tumour) for Pt 2. From the pre-therapy studies, the prescribed activities to be delivered would result in expected average doses and BEDs to normal liver of 22 (BED = 29) Gy and 33 (BED = 49) Gy for Pt 1 and Pt 2, respectively.
Average doses and costs were compared between the high-dose and medium-dose SYT and SED groups.
To estimate the drug acquisition costs (induction and maintenance) for both models during the progression-free period, the number of administrations, as reported in the PRONOUNCE trial, was combined with average dosing and unit costs for each drug within each regimen.
To that purpose, all different data were collapsed in one value for each patient (i.e. average Dose, AUC and CL vs median efficacy and toxicity scores).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com