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Second, to handle reservoir models with great heterogeneity in cell sizes, we investigate the use of rescaled sensitivities (average cell volume multiplied by local sensitivity density) in the inversion.
The average cell volume and surface area was 0.91±0.07 µm3 and 8.3 µm2, respectively.
Average cell volume of all isolates was 21.52 ± 5.56 μm.
The significance of differences in average cell volume among strains was determined using ANOVA.
Mechanical unloading induced a regression of hypertrophy, and average cell volume was smaller than for sham cells.
The average cell volume of the ancestral clone at stationary phase was measured as between 0.37 and 0.39 fl.
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Average cell volumes were measured using a Coulter particle counter (model ZM and channelyzer model 256).
(a) Average cell volumes of the TNBC cell lines 4175, SCP28 and SCP6 treated with RCA-I of different concentrations.
The average cell volumes were measured for over 300 Tetr transductants, and 91.5% produced large cell sizes consistent with co-transduction.
We initially chose ten clones that had average cell volumes of ≥0.44 fl, and we measured the competitive fitness of each relative to the ancestor.
For the co-transduction analysis using REL10247 as donor and the ancestor as recipient, we scored Tetr clones with average cell volumes ≥0.44 fl as having the beneficial allele, and those with averages ≤0.39 fl as having the ancestral allele; intermediate values were ignored when estimating the co-transduction frequency.
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