The phrase "average binding ratio" is correct and usable in written English.
It can be used in contexts related to chemistry, biology, or pharmacology, where binding interactions are being quantified or compared.
Example: "The average binding ratio of the drug to its target receptor was found to be significantly higher in the experimental group."
Alternatives: "mean binding ratio" or "typical binding ratio".
An average binding ratio was calculated ± one standard deviation.
The occupancy pattern of Htz1 (or Nap1) around special sites (such as TSSs, REG sites and TTSs) is represented with average binding ratio (log2) by aligning the binding profile for each gene at the special site.
To understand the organizations of Htz1 and Nap1 at promoters, we calculated the average binding ratio profiles for Htz1 and Nap1 by aligning the binding profiles for 5419 yeast genes at TSSs.
Although the average binding ratio profile of Htz1 near TSSs is similar in wild-type and deletion mutant strains, Htz1 binding is decreased at the promoter and increased in the gene body after deleting the chaperones.
About 400 bp from the TSS, the intensity of the average binding ratio profile for Htz1 is sorted as chz1Δ
To compare the binding dynamics, the PCC (Pearson correlation coefficients) of the average binding ratio (log2) profile for each gene cluster were calculated in the wild-type and deletion mutant strains.
We tested the relationship between the average binding ratios of Nap1 and Htz1 across TSSs and mRNA frequency using previously reported mRNA frequency data [ 38].
The average Htz1-binding ratio profile of each cluster was calculated around TSSs.
We compared the average Htz1-binding ratio profile around TSSs in wild-type and chaperone deletion mutant strains.
Our results showed that the average Htz1-binding ratio profile for TATA-less genes was higher than that for TATA box-containing genes in both wild-type and deletion mutants (Supplementary Figure S8).
After Lowess normalization the binding ratio of the duplicates were averaged and a Z score value was calculated for each spot.
