This article will discuss the biological rationale for using selective COX-2 inhibitors in cancer chemoprevention, and outline new avenues of research into toxic effects and tissue specificity that are necessary to allow their successful use in patients at risk for colorectal cancer.
For example, for dioxin-like chemicals (e.g., PCBs) one of the first avenues of investigation was the effects on cytochrome P450 induction based on the known activity of these compounds to increase cytochrome P4501A.
Interestingly, dysfunctional receptor underscores the inefficiency to transduce the signal of long-chain fatty acid [ 148], opening novel avenues of researches for antiobesity effects associated with n-3 PUFA.
An understanding of the origins of these beliefs is also needed, with potential avenues of study including the effects of tobacco dependence, the extent to which smokers' negativity is socially constructed or consistent across different cultures, and the influence of cognitive dissonance processes.
Instead, he will use water for effect, or avenues of pleached hornbeams and clipped yew hedges, the better to lead and surprise the garden explorer.
One of the potential avenues of exploring the possible protective effect of immunity is through studying recurrence.
It does, however, open potential avenues of modeling, such as the Prometheus effect.
Another research avenue is the effect of genetic variants of the host immune system on the composition and function of the gut microbiome.
This finding, that a gaseous molecule produced endogenously by cells can exert anti-inflammatory effects, opened new avenues of research in both experimental models of clinical disease and in human disease.
This finding may reflect the effects of multiple avenues of information or greater social exposure.
