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However, these differences were reduced after matching when compared to those before matching, Additionally, we cannot rule out the possibility of residual confounding, particularly due to differences in duration of disease or severity (e.g., HbA1c), which was not available in this database.
Using the Neisseria PubMLST Database, 431/461 (93.5%) isolates and 89/107 (83.2%) STs detected in the Basque Country were assigned to one of the clonal complexes available in this database.
We find that 54% (∼813 proteins) are localized in the cell cytoplasm, 12% in the membrane, 7% are secreted (likely from various intra-cellular granules), 13% show mapping as nuclear proteins and the remaining 14% did not have any sub-cellular localization information available in this database (Figure 9).
Certain patient characteristics were not available in this database.
Free text from medical records is not available in this database.
However, no polymorphism data are available in this database, and human enzymes are underrepresented.
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Although the reasons for this were not available in the database, we believe this reflects a variety of factors, including lack of investigator experience with home therapy, lack of patient demand for home therapy when clinic access was convenient, and the low comfort level of attending physicians and nurses with home infusion of an investigational drug.
H 2500 and H 1100 values are not available yet in this database.
Our examination of the sequences of this epitope available in the database also demonstrates that the protective epitope TVYHGAGTK was found in the majority of genotype 1b viral strains but not in genotype 1a (supplementary table 4).
We also explored an approach to investigate drug utilization for a drug which is started in hospital even though in-hospital prescribing information with a few exceptions is not available in the database providing data for this study.
Furthermore, no information is available in this administrative database regarding the reason for dose escalation – lack of efficacy, increase in symptoms, other reasons.
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