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Full biomarker and clinical data are not yet available from this study; however, clinical responses to pemetrexed treatment have been observed in patients.
In Figs. 6, 7, 8, and 9, we investigate these issues further, by analyzing the data available from this study to study how the four primary categories of challenges individually varied across activities.
RAS analyses are not yet available from this study.
Expression values for 3923 genes were available from this study.
The raw, unprocessed double-mutant fitness measurements were not available from this study.
Likewise, their strain table should indicate for which strains genome sequence and RNA-seq are available from this study.
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Based on the available data from this study, dose dependence of TEAEs cannot be assessed.
Unfortunately, no RNA is available from the study material to explore this hypothesis further.
Still the available model parameters from this study are comprehensive and self-consistent.
Single-dose efficacy data were available from this five-day study; efficacy data were not available for multiple doses.
To define housekeeping genes, we compared CRISPR screens from publicly available datasets40,41,42,43 and this study.
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