Existing data for other vaccines are available based on isolated case reports or small groups related to immunizations, and no conclusion about causality can be drawn.
Comparing the infectious disease reporting systems of The Netherlands and Germany we determined which routine data are available based on comparable case definitions on both sides of the border.
The ENM_1 used all suspected occurrence points available based on five years of reported human cases (2006 2010) and 17 environmental and socioeconomic variables after removing some variables that were found to have high multicollinearity with other variables.
All reports had to satisfy the following Inclusion criteria: published in peer reviewed journal or publicly available, based on research on humans, of cohort or case-control design, study location specified, any form of oral cancer as the outcome, and chewing tobacco, orally used moist snuff or unspecified smokeless tobacco as the exposure.
Hair collar sign (HCS) and hair tuft of the scalp (HTS) are cutaneous signs of an underlying neuroectodermal defect, but most available data are based on case reports.
Scant data on treatment of these infections is available and is based on case reports only.
Available information is either based on case studies, 9 10 parents' experiences of care throughout their babies' time in hospital 11 14 or experiences of parents in non-Western cultures.
Retrospective and prospective studies are available and some studies are based on cases identified through cross sectional antibody prevalence studies.
Available published data on prognosticators in prolonged hypoglycemic encephalopathy are based on cases series with a limited number of patients.
The primary and secondary outcomes will be based on available case analysis with a sensitivity analysis using multiple imputations, best case and worst case analysis.
We will recruit and have complete detailed case tracking for these approximately 400 cases from approximately 600 available cases (based on pre-study data) accounting for losses to attrition, inability to obtain consent, refusal to participate and incomplete records.
