Since patents restrict competition, there has been widespread concern during and since the TRIPS negotiations that the new laws would increase drug prices and availability, strain national health budgets and restrict access to essential medicines in India for the poorest populations.
Interestingly, in liquid cultures that had a rather low surface:volume ratio, which results in a poor aeration in turn leading to a low degree of Ci availability, strain 6714 grew slower compared with strain 6803 in the presence of increased NaCl concentrations (Fig. 6B).
It is possible that the groups of strains with class II pilE may expand with increasing availability of strain collections and whole genome sequences and consequently the association of class II pilE with strains that have particular epidemiological characteristics should become clearer.
The guinea pig model, despite limited availability of strain 13 animals, could provide valuable insight into pathogenesis, as well as insights into protective immune responses necessary for protection against primary and secondary arenavirus infections.
Taking advantage of the availability of strains that produce ARA de novo, we were able to show that in an engineered ARA producing strain carrying Pr Δ-17, the PL fraction contained higher percentage of EPA than either the CoA fraction, or the total lipid fraction under oleaginous condition.
Although deliberate transfers of Wolbachia across species remain particularly challenging, the availability of strains with desirable attributes should be expanded, taking advantage of the diversity available across thousands of strains in natural populations.
Because of its simplicity and the availability of strains with individual deletions in all of its genes, chemogenomic profiling in yeast has been used to identify drug targets.
Irrespective, as global approaches to gene expression continue to implicate members of the CSRNP family of genes in various physiological responses, the availability of strains of mice lacking the genes will be invaluable to critically assess their physiological role.
The availability of strains of partially transformed keratinocytes from premalignant erythroplakias which possess normal p53 genes should enable us to test the role of mutant p53 in the progression of erythroplakia to SCC.
The availability of strains in pure culture will enable investigation into resistance mechanisms, and work in progress indicates that mutations in region-V of the 23S-rDNA explain the azithromycin resistance (J.S. Jensen, unpub. data).
The medaka fish (Oryzias latipes) provides an ideal genomic vertebrate resource to study these issues, in part due to the ready availability of strains with substantial sequence divergence but continued cross-fertility.
