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The availability of these structures has also illuminated the action, selectivity, resistance and synergism of antibiotics that target ribosomes.
Whereas availability of these structures demonstrates government's ownership of the service quality improvement, much remains to be done to ensure well functioning service quality assurance system in the country.
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The availability of the structures and chemical shifts for all four components of this system now allows us to comment on the most likely contributions to the observed positive cooperativity.
The availability of these AChBP crystal structures has significantly improved our understanding on the overall molecular structure of the nicotinic receptor LBD and its molecular interactions with nicotinic ligands.
As the availability of 3D structures and structural alignments are still limited in protein comparison studies, the NCL-NNE prediction approach provides a useful option that can successfully predict important structural residues utilizing a single protein structure.
These performance variations were highly linked to the availability of PDB structures and to the structural diversity of the ligands that were co-cristallized in these structures.
These programs are widely used today since the increasing availability of protein structures has led to most biomedical researchers using structural information for the design and analysis of their experiments.
With the fast progress of Structural Genomics and the availability of multiple structures of functionally related proteins, methods like MAPPIS are expected to become increasingly useful.
However, these methods are limited by the accuracy of the initial query structure prediction and the availability of the homologous structures in the structural databases.
(76) However, these evolutionary relationships were derived prior to the availability of crystal structures of any members of the voltage-gated ion channel family, and before any prokaryotic sodium channels had been identified, information that now suggests some revision to these schema may be appropriate.
PI3Ks are well-understood in comparison to PI3K-related protein kinases such as TOR, due in part to the availability of structures for PI3K, including a structure for a Ras-activated form of PI3KCγ (9).
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