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The availability of the structures and chemical shifts for all four components of this system now allows us to comment on the most likely contributions to the observed positive cooperativity.
Given the public availability of the structures of the 8,193 unique compounds included in the Phase II > 10K library (U.S. EPA 2013e), we invite the scientific informatics community to predict the activity of these compounds in the different nuclear receptor and stress response pathway assays before public release of the data.
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Availability of the structure model of PfHslV may facilitate identification or designing of novel and specific drugs against PfHslV.
Future work will profit from the availability of the structure of Citrobacter freundii Dha kinase, which contains substrate-interacting residues conserved in human Dha kinase/FMN cyclase.
In particular, despite the availability of the structure of CP29 obtained at near atomic resolution in 2011 (Pan et al., 2011), the mismatch in pigment content and spectroscopic properties between CP29 in solution and in the crystal has hampered the possibility to use the structure to interpret the experimental data.
We also have condensed our description of the Norrin structure ("Production of biologically active Norrin"), and rearranged Figure 2 and Figure 2 figure supplement 3 to address the reviewers' comments and fully exploit the availability of the structure from the prior studies of Ke et al., (2013).
However, these methods are limited by the accuracy of the initial query structure prediction and the availability of the homologous structures in the structural databases.
The availability of these structures has also illuminated the action, selectivity, resistance and synergism of antibiotics that target ribosomes.
The availability of the NP7 structures now allows the combination with the studies of fast dynamics of the ligand-protein interaction.
As is the case for the design of novel pharmaceutical agents, the successful application of docking methods to problems in chemical toxicity depends on the identification and availability of the crystal structures of the macromolecular targets or similar proteins.
Even the availability of the 3D structures of the visual rhodopsin and other GPCRs [ 7, 8, 25– 28] and of several MRs [ 2, 16, 29– 31] did not clarify the evolutionary relationship of the two protein families.
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CEO of Professional Science Editing for Scientists @ prosciediting.com