All subjects performed a right-handed 3-choice button press task, which controlled the availability of repeatable responses.
The different pattern of results between the 2 tasks suggests that patients on dopaminergic therapy may be sensitive to the availability of the responses in the action-selection trials.
If the components previously observed during cued unimanual response preparation were critically dependent on the availability of full response information required to activate a complete motor program, they should be entirely absent in Experiment 1, where only partial response information was provided.
Limitations of this study include the availability of immune response data for only a subset of patients, and the post hoc correlative nature of the analyses.
Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited.
One reason for limited application of QMRA to microbes capable of causing respiratory infections may be the limited availability of dose-response functions, which are complicated by uncertainty about mechanisms of disease transmission.
Perceived control, e.g. the perception of, or belief in, the availability of a response that can reduce or limit pain, has been associated with less pain reports and an increased pain tolerance [ 1].
Thus, the 7-repeat allele of DRD4 is thought to be associated with blunted receptor response to dopamine stimulation, and the 10-repeat allele of the dopamine transporter gene is thought to be associated with increased expression of the transporter protein, both hypothesised to result in an overall decrease in availability of or response to dopamine [ 2].
The strengths of this study include a homogeneous patient population, the availability of detailed response, outcome and toxicity data in all patients, first-course PK data of MTX in most patients, as well as population PKPD analysis of HD-MTX time concentration data.
Neoadjuvant chemotherapy may improve survival, but targeting treatment to patients who respond to chemotherapy could be improved by the availability of markers of response.
