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The availability of conditional knockout mice and transgenic mice that express candidate hypomorphic EpCAM alleles will allow EpCAM function to be additionally explored in embryonic development, reproduction, and adult physiology.
The recent availability of conditional knockout mouse models that recapitulate, to a large extent, type 1 and nGD symptoms has significantly advanced the field, as will the availability of a large animal (sheep) model.
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Certainly, the availability of the conditional in vivo model described herein will allow the field to uncover the basis of the sensitivity of developing neurons to TDP-43 misregulation.
The availability of a conditional Frabin/ Fgd4 null allele allowed us to also address the physiologically and pathophysiologically important issue whether Frabin/Fgd4 is required for the maintenance of properly developed myelin, independent from the role of Frabin/Fgd4 in myelination during development.
With the availability of the new conditional alleles reported here, it will be important to investigate Mafb's activities in other regions of the nervous system in the future.
However, the availability of mice bearing conditional alleles of essential mTORC1 and mTORC2 components has made it possible to begin to dissect the physiologic functions of these signaling complexes using cell-type-specific Cre drivers (Chen et al., 2008; Gan et al., 2008; Gan and DePinho, 2009; Kalaitzidis et al., 2012).
Examples of conditional data availability include the Korean Renal Registry (available for academic purposes only), the US Renal Data System (USRDS; available through a registry coordinating center or through a third party approved research team and request), and the Dialysis Outcomes and Practice Patterns Study (DOPPS; potentially available to corporate sponsors).
Ideally, a central repository by manufacturers for the identification and instructions for use and MRI conditional availability of all their devices, should be created for cardiologists, radiologists and referring clinicians.
Mice exhibit a morphologically analogous form of small intestinal villus epithelial cell shedding to that observed in humans and have the potential to allow important mechanistic insights because of the availability of established transgenic and conditional mutant models.
The results indicate the predictive performance in global water availability is conditional on the climatic condition.
We conclude this section by noting the availability of multivariate distributions with Pareto conditionals rather than Pareto marginals.
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