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Separation and enrichment technologies behavior of AMPS emanates from: (1) high water uptake, (2) availability of an active sulfonic group and (3) also having the functional amide group.
In the case of sensing applications based on surface binding detection, the availability of an active surface area on the top of pores vs. a surface area inside of pores could also have an impact on the sensitivity of the RIfS device.
The activity and thiol reactivity of the Grx1 trapping mutant was confirmed in independent experiments (data not shown), thus demonstrating that the mere availability of an active site thiol does not explain the profile of proteins captured by the Trx1 trapping mutant.
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Suppressing the availability of a new active agent in order to not impede trials with old drugs would be decidedly unethical.
Following the positive OS results from E4599 [ 9], the study protocol was amended to facilitate trial completion and interpretation, to accelerate reporting of the efficacy data and thus expedite the availability of a potentially active treatment option for patients and to minimise the risk of the OS end point being confounded by the increasing use of second-line therapies.
Despite the availability of a number of Active Disassembly concepts which offer significant potential to make systematic product disassembly economically viable, the stage of mass industrial implementation has not yet been reached.
This can be attributed to the low surface area of the bulk Mo2C, which leads to a low availability of Mo2C active sites on the surface of material (which is different from the high-surface-area metal carbide materials prepared by Claridge et al. [9].).
Subsequently, a major drawback is the limited availability of human oocytes, a problem which could be circumvented with the possible availability of biologically active recombinant human zona as a substitute, along with other chemical/biological candidates [ 56– 56].
The plasma drug exposure (expressed as AUC and Cmax) observed in the ABZ treated animals (Experiment 1) was in agreement with data obtained in the previous studies, which indicate that the low ABZ efficacy was not related to the quality of the pharmaceutical product and/or to a low systemic availability of the active drug/metabolite.
43 This trend might be due to the availability of new active drugs and to a more adequate selection of patients for surgery.
Against this background, and despite training and the availability of stipends, active mentorship was mostly a low priority, bringing into stark relief the conundrum of having to build capacity with very limited capacity [ 12, 42].
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