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Understanding the role of endogenous GLP-1 in metabolic physiology has been greatly enhanced by the availability of a potent GLP-1 receptor antagonist, exendin- 9 39).
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Despite availability of a substantial number of potent synthetic drugs, medicinal plants are still playing a key role in the discovery of novel and effective drug molecules.
Tuberculosis (TB) remains among the most deadly health threats to humankind despite availability of several potent antibiotics and a vaccine, bacille Calmette-Guérin (BCG).
Food availability is a potent environmental cue that directs circadian locomotor activity in rodents.
The Mannose 6 Phosphate/Insulin-like Growth Factor Receptor-2 (IGF2R ) encodes a type-1 membrane protein that modulates availability of the potent mitogen, IGF2.
In the past 10 years the implementation of adequate legislation fostering controlled clinical trials in children and the availability of new potent medications such as the biologicals have led to a dramatic improvement in the treatment of systemic and non-systemic JIA [ 4].
Although some believe we should limit the number of drugs in a single class which receive FDA approval, taken to a logical conclusion, this policy would have limited the availability of more potent statins with improved efficacy, as well as other multiple beneficial effects.
However, pharmacological studies on this receptor have been impeded by the limited reported availability of stable, potent and selective P2Y2R antagonists.
The availability of more potent inhibitors of gastric acid secretion and the increasing demand for maintenance therapy has renewed interest in the potential side-effects of profound and/or long-lasting therapy.
With the availability of such potent and diverse agents it is now possible to develop multi drug regiments that can depress the immune system at the different steps of the activation cascade, with minimal side effects, thus improving graft and patient survival rates.
The availability of highly potent strains of marijuana and marijuana-derived concentrates is nothing new.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com