Both H2O-PET and xenon enhanced CT use is limited by cost, availability and methodological problems.
In part, these difficulties exemplify the general lack of understanding and availability of methodological tools for enhancing research utilization.
Likely explanations include the availability of a methodological guidance (ie, the Cochrane Handbook), and the use of standardised tables in Cochrane (ie, the Cochrane RoB tool).
Selecting the study design is a compromise between methodological constraints, availability and ease of access to data sources and resources available.
Relevance, comprehensiveness, availability, context-appropriateness, affordability, methodological rigor, timeliness, and representation of country situation were characteristics of robust evidence as perceived by policymakers.
Most respondents felt that the methodological rigor, availability of survey reports, relevance, and ease of obtaining the information from these surveys were also what made it especially useful.
Together with the increasing availability of genotypes, further methodological developments are expected to increase the reliability of GEBV and to achieve higher genetic progress.
However, a significant limitation in the investigation of oxidative stress in toxicology has been the availability of an integrated methodological approach for real-time detection of reactive oxidant species and oxidative damage in living cells.
Results also imply that controlling/manipulating food availability may be an important methodological aspect in neuroscientific eating research.
Some proposed solutions argue for transparency and stress the availability of raw data and methodological details as the principal means of enhancing credibility (Borgert 2007; Schreider et al. 2010).
It is plausible that part of the variation of the quality of reporting between RCT reports can be explained by other variables such as awareness of the CONSORT statement by authors, adoption of CONSORT by journals and availability of advice from a methodological expert when planning an RCT.
