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Throughout the progression of CKD, increasing loss of functional renal tissue reduces the availability and function of 1α-hydroxylase, which in turn disrupts overall vitamin D production, metabolism and hormones [ 35].
It has been described that age and other cardiovascular risk factors reduce the availability and function of EPC, thus limiting their therapeutic applicability in affected patients [39] [41].
Recent studies suggest that Merlin directly controls the surface availability and function of membrane receptors that regulate proliferation and differentiation in both Drosophila and mammalian cells.
Moreover, the availability and function of EPCs are also adversely affected by risk factors for cardiovascular diseases, including hypertension, diabetes, cigarette smoking, physical inactivity, homocysteine levels (HCY), and aging [ 3].
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Technology: risk factors regarding the availability and functioning of technology, 4.
Purpose / Objective The ultimate objective is to provide comprehensive information on the availability and functioning of STDs/HIV/AIDS services in Somalia, so that needed improvements and expansion can be planned and implemented.
Next the two authors met to discuss and agree the number of each of the higher-order domains, and to label and define them (eg, equipment and supplies was defined as 'the availability and functioning of equipment and supplies').
In relation with general health goals of a district, concretisation and prioritization of infrastructural measures is facilitated (for example, 'improve rain water harvesting potential and its utilization at health centres in region X' or 'improve availability and functioning of basic sterilization equipment in dispensaries of Y district').
Data were collected on aspects of care provision including availability of drugs and supplies (restricted to presence or absence and recent stock outs), and availability and functioning state of equipment.
In fact, HS chains can bind large number of proteins and several bioactive molecules like growth factors, chemokines, cytokines and enzymes to the cell surface and ECM, thereby regulating their availability and function in the control of some physiological processes, such as cell-cell and cell-ECM interactions [ 7].
Therefore, this system may be suitable for studying the effect of physiological parameters such as ∆pH, ∆pmf, and substrate availability on the structure and function of F1Fo ATP synthase (Walker, 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com