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SIRT1 is sensitive to levels of the coenzyme nicotinomide adenine dinucleotide (NAD+), making NAD availability a potential regulator of the molecular circadian clock (Grimaldi et al. 2009).
Our results suggest the possible benefit of manipulating an intrinsic aging pathway that is independent of nutrition availability, a potential therapeutic route that might be able to bypass shortcomings of calorie restriction.
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That all but eliminates him from returning before the season ends Sept. 30 and jeopardizes his availability for a potential postseason appearance.
BOGUT OUT Andrew Bogut, the Milwaukee Bucks' leading scorer and rebounder, has a broken hand, a dislocated elbow and a sprained wrist, injuries that will keep him out indefinitely and cast doubt on his availability for a potential playoff run.
The uncertainty around Pardew's position is being played out with the club's hierarchy – including the American co-owners, David Blitzer and Josh Harris, who will have a significant say on what happens next – acutely aware of Sam Allardyce's availability as a potential replacement.
He remained in the league's concussion protocol eight days after absorbing a hit to the head in the loss in Houston, jeopardizing his availability for a potential date with the star receiver Odell Beckham Jr. Bowles was uncertain whether Revis had begun physical activity.
The proportion of postings that were for primary care varied widely by state (9% to 40%) and were highest in the West.Job availability is a potential barrier to PAs practicing in primary care, especially in some locations.
While survey evidence suggested that small businesses considered weak demand to be a larger problem than access to credit, participants saw limited credit availability as a potential constraint on future investment and hiring by small businesses, which normally are a significant source of employment growth in recoveries.
Finally, the availability of a potential in vitro hypnozoite model opens the way to conduct detailed investigations into the nature and mechanisms of latency in Plasmodium parasites, a hitherto closed avenue of fundamental biological interest.
Donor availability is a potential barrier for patients who are candidates for allogeneic HCT, but lack an adequately human leukocyte antigen (HLA -matched and clinically suitable sibling donor.
Sugarcane bagasse was utilized as a model substrate for the saccharification experiments due to its availability as a potential lignocellulosic feedstock in Brazil.
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