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Very low birth weight (VLBW) preterm infants are at risk for impaired cerebral autoregulation with pressure passive blood flow.
Flow velocity responses to spontaneous or induced (with vasopressors) changes in CPP may quantify the status of static pressure autoregulation; autoregulation estimated by TCD in the middle cerebral artery correlated with autoregulation studied by positron emission tomography in TBI patients [ 28].
Hyperoxia significantly improved pressure autoregulation.
Pressure autoregulation is generally preserved during hypothermic cardiopulmonary bypass.
Pressure autoregulation was impaired in these head-injured patients.
Interestingly, blood pressure autoregulation of CBF remains intact [ 108].
● Cerebrovascular pressure autoregulation was impaired in half of the patients treated for severe ICH.
Endothelial dysfunction would probably affect pressure autoregulation rather than CO2 reactivity.
Vasoconstriction induced by hyperoxia may partially contribute to the improved pressure autoregulation.
These findings are in accordance with previous publications on TBI, which demonstrated cerebral heterogeneity in terms of circulation, pressure autoregulation, critical closing pressure, oxygenation, and metabolism.
Our results suggest that sepsis-associated delirium, but not sepsis per se, is associated with impaired pressure autoregulation.
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