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We found that categories III and IV, both of which have no autoregulation on the intermediary regulator, were consistently underrepresented, while in sharp contrast, categories I and II, both of which have autoregulation on the intermediary regulator, were overrepresented.
In particular, we found that an FFC composed of two repressor regulators with autoregulation on each of them is a significant network motif.
Regarding the regulator chain backbone, autoregulation on the intermediary regulator was shown to be a significant factor for a higher frequency of appearance than expected in the random networks.
At the same time, it represses the transcription of Bmal1 gene through exerting a negative autoregulation on the pathway [ 54], and this regulatory effect of BMAL1 is described as a direct and negative autoregulation type.
To examine the influence of autoregulation, we classified the FFCs according to the presence or absence of autoregulation on each regulator of an FFC without respect to the regulators' modes.
Reinhard et al 16 found that impaired cerebral autoregulation on the affected side was associated with poor clinical outcome after a mean 4 months of acute ischaemic stroke onset.
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Finally, we provide context and a proposed model integrating our knowledge on autoregulation of the receptor and its functions in the liver.
This is due to the trypanosome having evolved a population survival strategy based on autoregulation of parasitaemia and antigenic variation (MacGregor et al., 2011; Horn, 2014).
While redistribution of medullary blood flow has yet to be demonstrated experimentally, it provides a tantalizing explanation for the conflicting data on autoregulation of MBF and merits further investigation.
Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney.
Our previous NHK colony formation model [3] mainly focused on the autoregulation of NHK colony formation [13] [17].
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