As we did not measure coronary blood flow in our population, no association between the arterial blood pressure at terminal cardiovascular collapse and the lower threshold of coronary autoregulation can be made.
Moreover, it would be interesting to understand what specificities of post-transcriptional autoregulation by miRNAs can make them better suited to fullfil certain tasks with respect to the trascriptional self-regulation, so widely used in bacteria [ 30].
Since changes in PaCO2 induced by hypoxia and hyperoxia may in themselves affect cerebral autoregulation, an attempt was made to keep the volunteers isocapnic by continually monitoring and adjusting end-tidal CO2 (PETCO2) during the cerebral autoregulatory assessments.
Impaired autoregulation renders the brain susceptible to episodes of hypoperfusion/ischemia, which can weaken blood vessels making them prone to rupture during episodes of hyperperfusion leading to hemorrhage.
Autoregulation is sometimes impaired in neurocritical care patients, such that CBF becomes directly dependent on CPP, making the brain more vulnerable to both hypo- and hyperperfusion [ 30- 32].
This makes bistability possible even without autoregulation, but only when we add autoregulation to the model or modify the parameters do we see bistable behavior (data not shown).
Examples where recent progress has been made include aspects of autoregulation, signal integration in branched pathways, cross-talk suppression, and cross-regulation via connector proteins.
The fact that optimal CPP and autoregulation status varies between individual patients and over time makes it an attractive bedside tool to serve as a (simplified) model to investigate the use of autoregulation (PRx) status to fine tune or feedback clinical treatments in individual sedated TBI patients (optimal CPP concept) [ 1].
Dulloo AG, Jacquet J, Montani JP, Schutz Y. How dieting makes the lean fatter: from a perspective of body composition autoregulation through adipostats and proteinstats awaiting discovery.
This makes them better candidates than healthy subjects with intact cerebral autoregulation in order to show proof of concept.
