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We further provide evidence that Dlk1 non-cell autonomously affects satellite cell fate choice between self-renewal and differentiation.
To examine whether KRAP autonomously affects the expressions of lipogenic enzymes in cells, RNA interference-mediated suppression of KRAP in HepG2 cells was performed.
Together, these data indicated that SSCs' self-renewing ability was non-autonomously affected by mutant Sertoli cells.
Taken together, these data suggested that the cytoskeletal changes due to AIP1 deficiency caused specific defects in E-cadherin localization for both germ cells and Sertoli cells and that E-cadherin or cytoskeletal defects in one cell type non-autonomously affected E-cadherin distribution of the other cell type.
In adult males subject to ecdysone deficiency, the CySC's lineage overproliferates, expresses epithelial markers, and non-cell-autonomously affects germline differentiation.
Therefore, we propose that upon stress and ecdysone deficit, Ab acts as a regulator of gene expression to adjust function and form of epithelial cells of the germarium, which cell non-autonomously affects the germline differentiation speed.
Our studies do not address autonomy of function of genes in QL, and these genes might act autonomously with mab-5 in QL, or might non-autonomously affect Q migrations along with mab-5 in other mab-5-expressing cells in the posterior.
E18.5 is a time-point where the severe growth defects could have already affected the NSCs non-cell autonomously before isolation, perhaps due to a systemic reduction in IGF2 (Hansen et al., 2004).
In the money model, the supply of money is treated with the same simplicity that was accorded investment in the income model as "autonomously" determined, which is to say that it is not affected by other factors: Ms = M̄.
Chimeric animals obtained by blastula transplantations revealed that in the case of shd, rse and tra the genes are autonomously required in iridophores, while mutant melanophores and xanthophores are not affected and can form normal stripes when confronted with wild-type iridophores (Frohnhöfer et al., 2013; Krauss et al., 2013).
In budding yeast, origins (or autonomously replicating sequences ARSs) have defined DNA sequence requirements, but their activity and timing is affected by chromatin context and histone modifications [ 7– 9].
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