Interestingly, Sirt6-deficient animals develop profound lymphopenia as a result of a cell non-autonomous mechanism, suggesting a possible defect of relevant cytokines or growth factors involved in T cell function [31].
These autonomous and non-autonomous effects suggest that the control of size in the wing is the result of local cell communication defining canonic distances between cells in a positional-values landscape.
Although Wallace acknowledges that the Model S isn't designed to be fully autonomous, he suggests that Tesla may need to reconsider its stance on Lidar if it's to achieve its self-driving ambition.
The non-cell autonomous effect suggests that endodermal cells with inappropriate RA signaling levels signal to their neighbors either directly or via the mesoderm to repress CdxA.
This potential autonomous activity suggests that PKMζ might be an important player in LTP maintenance.
Importantly, these effects were cell autonomous, which suggested that it may be possible to use spine density as a biological read-out of PTEN function.
Overall, the diversified Rover families, the relatively high number of Rover elements (including MITEs), and the presence of autonomous copies suggest that these elements have been particularly active in the whole clade until recently (fig. 1 B).
The fact that all sequenced symbionts of the Auchenorrhyncha, despite millions of years of divergence and several replacements, encode relatively autonomous pathways suggests that the host and companion symbionts cannot contribute interspersed steps in the synthesis of essential amino acids.
The confinement of pSmad2 staining to the tumour cells, and ability to inhibit metastasis by blocking TGF-β signalling in a tumour cell autonomous manner suggests that TGF-β produced by tumour cells acts on tumour cells to mediate cell invasion and metastasis.
