To prove a cell autonomous and specific role for Gfi1, we transduced Gfi1−/− LSK cells with retroviruses encoding Gfi1-GFP and GFP, respectively, and cultured these genetically modified cells in SCF and IL7 containing medium.
To exclude the additional wound ethylene from the autonomous tissue specific ethylene production level, one needs to know when wound ethylene sets in and becomes observable.
This destructive operation induces the wound ethylene response and should be taken into account in order to exclude the wound induced ethylene production from the autonomous tissue specific ethylene production capacity.
Here we study population characteristics using spatially explicit IBMs where the overall population dynamics emerge solely as a result of individuals' independent and autonomous site-specific behaviors [32], [33].
Once established, liver disease could be adoptively transferred by T cells independently of NKT cells and microbes, illustrating the importance of early microbial activation of NKT cells in the initiation of autonomous, organ-specific autoimmunity.
Our in vitro findings suggest that the observed high expression levels of innate immunity genes that have been reported in lesional skin of psoriasis patients compared to atopic dermatitis[4], [5], can be caused both by extrinsic factors (cytokines) and cell-autonomous (disease-specific) factors.
All of them take into account cell-autonomous (cancer-specific) properties and are known as (i) genetic streamlining, (ii) oncogenic shock and (iii) synthetic lethality (SL).
105 Although its influence on HGSNAT expression requires further investigation, SVA elements are known to be non-autonomous, hominid-specific, non-long terminal repeat (LTR) retrotransposons that possess the capacity to sporadically generate disease-causing insertions.
Bhattacharya said she couldn't comment on their specific autonomous plans, but that the Maven Gig program does offer a "lot of nice learning opportunities and synergies" in that area.
We anticipate that such biomimetic hydrogel walkers could form the basis of light-actuated soft robots capable of more advanced functions, such as autonomous migration to specific locations accompanied by triggered release of molecular cargo.
