Next, we studied vascular morphogenesis in vitro by exploiting the permissive activity of Matrigel, a natural laminin-containing basal membrane matrix that unleashes the cell autonomous property of cultured ECs to self-aggregate and morphologically differentiate in tubular networks almost identical to those observed in vivo.
(1) The progressive restriction model, in which immature mTECs mimic gene expression programs of distinct tissue-specific cell lineages and preserve cell-type specific gene regulation, and (2) the alternative terminal differentiation model which proposes that a random pattern of promiscuous gene expression is an autonomous property of mature mTECs.
SAC contains both acetylcholine (ACh) and GABA [14], [15], and GABA plays a critical role in the computation of motion direction: blocking GABA receptors abolished DS [16] and the asymmetrical responses in its varicosities are mediated by reciprocal GABA inhibition [10], in addition to cell autonomous properties [9].
This may be interpreted to mean that the expression of the 2 genes reflects extracellular environmental factors, rather than the cell autonomous properties of cortical neurons.
To further illustrate the potential use of the Speedy cell line, we asked if we could use it as a model to investigate the cell autonomous properties of the thyroid hormone signaling pathway.
We still do not know if sex differences in the function of female adipocytes are mainly derived from genetic, cell autonomous properties related to sex chromosomes or from critical early imprinting events by sex steroids.
A tumor has been recognized as a complicated "organ," other than a simple collection of relatively homogeneous cancer cells, whose entire biology could be understood by elucidating the autonomous properties of these cells.
Previous studies have found PTX3 levels to be correlated with CRP, IL-6, and elevated levels of MIF, which are known to control autonomous properties of tumour cells, such as proliferation, apoptosis, DNA-damage response, senescence, and invasion (Dessein et al, 2010), in the tumour and serum of pancreatic cancer patients (Winner et al, 2007).
The metabolic cycle was shown recently to be a cell-autonomous property of yeast cells, observed in a variety of conditions [30].
However, small subsets of SCs are LRCs and retain self-renewal potential in pathogenic muscle, implicating a cell-autonomous property of LRCs to maintain self-renewal potential.
Lastly, in addition to models that rely on cell-autonomous properties, recent data from Felsher and colleagues suggest that non-cell autonomous effects might deserve consideration in the context of oncogene addiction and 'synthetic lethal' heterologous cell cell interactions.
