Sentence examples for autonomous gene from inspiring English sources

Pancreatic endocrine cells are produced from a dynamic epithelium in a process that, as in any developing organ, is driven by interacting programs of spatiotemporally regulated intercellular signals and autonomous gene regulatory networks.

Thus, tef1 appears to be not the only mediator of light induced cell autonomous gene expression in PAC2 cells.

At this point it was important to consider that if CbfA-CTD had autonomous gene regulatory functions, as described above, then the protein must be expected to enter the nucleus without the help of the remainder of the CbfA protein.

Although expected to be a very rare event, accidental integration of such a plasmid at the gRNA target site could create an autonomous gene drive.

We contrast our method to recently developed autonomous gene drive technology for somatic and germline genome engineering and conclude that optimized CRISPR with independent transgenes is as efficient, more versatile, and does not represent a biosafety risk.

However, there are major biosafety concerns about the use of autonomous gene drive technology in the laboratory because of the risk of accidental infiltration of autocatalytic alleles into wild populations (Esvelt et al. 2014; Oye et al. 2014).

One pathway involves a set of autonomous genes (which are turned on at a specific developmental stage), a second pathway involves genes that are responsive to the photoperiod, and a third pathway includes genes that respond to the phytohormone gibberellin.

Transcription factor FoxN1 is an epithelial cell-autonomous gene, predominantly regulating development of thymic epithelial cells (TECs) and skin keratinocytes.

The known role of clocks in regulating cell-autonomous gene expression suggests that a circadian clock within pancreatic beta cells regulates levels of one or more proteins of the glucose-sensing and/or insulin secretion pathways.

Once the population has been established, it appears to use cell-autonomous gene regulatory networks fuelled, as in the embryo, by FGF/ERK signalling for its maintenance and differentiation.

Related article in GENETICS : Maher, K. N., A. Swaminathan, P. Patel, and D. L. Chase, 2013 A novel strategy for cell-autonomous gene knockdown in Caenorhabditis elegans defines a cell-specific function for the G-protein subunit GOA-1.