The phrase "autonomous changes" is correct and usable in written English.
It can be used to describe modifications or alterations that occur independently or without external influence.
Example: "The system is designed to implement autonomous changes based on user behavior and preferences."
Alternatives: "independent modifications" or "self-directed alterations".
Indeed, aging-related, cell autonomous changes have also been shown to contribute to altered HSC function [ 28, 36- 38].
In our opinion, in situ hybridizations would not provide further insights on the relative contributions of signalling and cell autonomous changes to the phenotype.
While these differences could be due to cell autonomous changes in gene expression induced by androgen programming, recent work suggests they could also be influenced by the location from which the fibroblasts were harvested (topology).
However, these studies were not able to determine if the altered metastatic potential of these tumors is due to non cell autonomous differences in the tumor environment or to cell autonomous changes in the behavior of individual tumor cells.
The increase in the circulating levels of inflammatory cytokines reflects cell autonomous changes in myeloid gene expression resulting in microenvironmental changes that could favor tumor initiation and progression [ 23].
This approach will be particularly powerful in revealing how the developmental trajectories of cells and circuits are altered, what are the primary cell autonomous changes due to 'direct hit' of the mutant gene, and what are the secondary, possibly maladaptive changes that lead to aberrant circuit-level operations.
This ratio thus indicates the financial investment that is needed to gain a certain treatment effect, based on the assumption that autonomous change regarding the patients is negligible.
The metastatic conversion of a tumor cell involves cell-autonomous changes which alter cellular cross-talk in the tissue environment.
mTORC1 inhibition by PRAS40 prevents cell-autonomous changes in cardiomyocytes that are responsible for the heart dysfunction in diabetic cardiomyopathy.
These could relate to the abnormal endothelial cell morphology but could also reflect cell-autonomous changes of pericytes as well.
Tumor cell-autonomous changes alone are not sufficient to allow tumor progression and metastasis to occur [ 7].
