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For each eye, we exported the SVP, DVP, CC and choroid en face OCTA scans, which were automatically segmented by the Angioplex™ software, as previously described26,27.

(1) To collect a dataset of normative Early Treatment Diabetic Retinopathy Study ETDRSS) thickness map values for single retinal layers automatically segmented by Spectralis (Heidelberg Engineering, Heidelberg, Germany) spectral-domain OCT (SD-OCT) in a healthy white population.

Hippocampi in subject images were automatically segmented by using AIR, SPM, FLIRT, and the fully deformable method of Chen to align the images to the Harvard atlas, MNI atlas, and randomly selected, manually labeled subject images ("cohort atlases").

Cells were then automatically segmented by successive morphological operation involving h-dome extraction, gray-scale reconstruction [43], [44], binary images, and morphological opening.

> -wrap-foot> Alesionsons were automatically segmented by an operator (Y.T).

Given the fissures detected, the lobe borders were automatically segmented by fitting an atlas with complete fissures (see van Rikxoort et al. [ 10]).

The prosthesis and the cortical bone of the tibia and fibula distal to the prosthesis on the 12 MR-acquisitions obtained were semi-automatically segmented by an imaging expert in approximate 30 min per acquisition using Mimics.

Short-axis cine stack and a long-axis cine slice of both ventricles were obtained with a section thickness 6 mm, intersection gap 20%, and temporal resolution 42 49 ms. The left and right ventricles and epicardium were semi-automatically segmented by a technician together with a radiologist from each time frame of the cine MRI series with a software tool developed for this purpose [18].

Previously, infarcted areas were semi-automatically segmented by thresholding the left ventricular myocardium to the mean +2 × SD values of unaffected myocardium.

Note that Fig. 15a shows the WSI with the manually labeled epidermis contour, while Fig. 15d, g, j, m shows the corresponding automatically segmented results by the MCGT [3], CET [23], GTSA [22], and the proposed technique, respectively.

In the proposed CAD system, the breast region is automatically segmented to avoid false detections caused by enhancing tissues of the heart and vessels outside of the tested breast.