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To tackle these challenges, automated optimization methods, which can work irrespective of the considered scenario and yet avoid a large number of network trial runs, need to be investigated.
These automated optimization methods are excellent tools for identifying gaps in network reconstructions and proposing candidate reactions to fill these gaps and fit the model to growth data, however, they often do not associate genes with the candidate reactions.
We note that due to stepwise optimization process in this method, the PC parameters for RUEs may not be optimal after Step 4. Nevertheless, simulation results in Section 6.2 will show that automated optimization methods, which jointly optimize PC parameters, and this manual optimization method can achieve similar performances.
For a given application, there can be numerous software topology alternatives creating the need for automated optimization methods.
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In the current study, we demonstrate an automated optimization method based on the Levenberg-Marquardt algorithm for electron-optical systems, incorporating an adaptive merit function switching process that enhances minimization convergence.
A global automated optimization design method targeting minimum fresh water consumption, which is based on sequential operation model, is presented, and the mathematical formulation is a MINLP, which can be solved by the computer code based on the hybrid genetic algorithm.
Numerical simulations are performed using the finite element method concomitantly with the automated optimization procedure.
In these situations, automated optimization techniques are natural candidates.
An automated optimization flow contributing HW and SW optimizations makes our model further a valuable tool for system synthesis.
It is this type of deep insight married to instant, automated optimization that will begin to move the ROI needle.
Though fraught with obstacles, studying the effects of product configuration on DfD will be useful to develop automated configuration optimization methods for EOL disassembly.
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