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This result emerged from an experimental strategy that combines the advantages of parallel, automated experimentation with the design of experiments (DOE) for the effective definition of an optimal set of reaction conditions.
Automated experimentation in microwell plate formats is widely used in high throughput drug discovery.
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At Brookhaven he would design a room-size, tube-based computer he named Merlin, as part of an early generation of computer systems used to automate scientific experimentation.
For such a screening, a novel cultivation platform for automated high-throughput experimentation [ 32] was used.
Liquid cultivation allows automated culturing and experimentation and should be of use in large-scale growth and screening of animals.
As detailed in [ 18], ISEA is a standalone system that comprises CULTURE analogue and system-level components for semi-automated experimentation and analysis.
The discovery and development of new products and active ingredients (AIs) thus rely on reaction screening and route scouting with high-throughput experimentation incorporating automated solid and liquid handling for rapid and routine screening (e.g. evaluate typically 100 reactions simultaneously at 1 mL scale) [19].
Our MyoRobot combines optical force transducer technology with high precision 3D actuation (e.g. voice coil, 1 µm encoder resolution; stepper motors, 4 µm feed motion), and customized control software, enabling modular experimentation packages and automated data pre-analysis.
Currently, NMR-based applications are the only approaches that can offer fully automated and highly reproducible high-throughput experimentation in a very cost-effective manner [ 6, 7].
Automated chemistry workstations equipped for parallel and adaptive experimentation can provide a significant impact in chemistry research, particularly for exploring search spaces as part of optimization studies.
We report the development of a multi-platform, user-friendly software tool MUSCLE (multi-platform unbiased optimization of spectrometry via closed-loop experimentation) for the robust and fully automated multi-objective optimization of targeted LC-MS/MS analysis.
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