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In order to check if the enhanced B-cell response in the absence of Carabin could lead to autoimmunity, we analysed the development of autoantibodies and autoimmune signs in Carabin-deficient mice.
However, and most interestingly, the subtle phenotype of Carabin-deficient mice and the fact that they do not develop autoimmune signs by their own do not argue against a role of Carabin in the genetic susceptibility for SLE development in humans.
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The clinician should consider TBDs among the differential diagnoses when approaching autoimmune-like signs in areas of tick infestation.
None of the patients acquired potentially graft-related autoimmune disorders or signs of hypersensitivity.
Further, we aimed to investigate the association of anti-p70 and/or anti-p80 antibodies with the presence of clinical signs, autoimmune diseases, and their respective autoantibodies.
Subjects had no evidence of A, B, or C virus or autoimmune hepatitis; clinical signs or symptoms of inborn errors of metabolism; history of toxins or drugs known to induce hepatitis; or history or symptoms of any known disease, apart from diabetes.
One reason for the difference could be that the median follow-up time in our study was 45 months, but the typical systemic autoimmune disease symptoms, signs and serum biomarkers were generally first observed at times between 48 and 66 months of follow-up.
The control group consisted of 80 anonymous healthy volunteers who did not show any clinical or laboratory signs of autoimmune skin diseases, as well as kinship with patients suffering from autoimmune skin diseases.
Patients with intracerebral or subarachnoidal haemorrhage, chronic inflammatory diseases like multiple sclerosis, autoimmune diseases, seizures without signs of CNS-infection, symptoms traced back to psychiatric indispositions or meningitis signs of undefined etiology were excluded.
Besides an increased susceptibility to infections it frequently presents with signs of autoimmunity, notably autoimmune cytopenias and rheumatic diseases.
All patients with silicone implants presented with silicone implant incompatibility syndrome (SIIS), whereas none of the patients with saline or mixed implants presented signs of autoimmune disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com