Sentence examples for autoimmune defects from inspiring English sources
The transforming growth factor-β (TGF-β) signaling pathway is essential in regulating the immune response to combat infection [ 8], and defective TGF-β signaling leads to several systemic autoimmune defects.
Although cancer is the most frequently studied phenotype other diseases related to cardiovascular, neurological and autoimmune defects reveal variations regarding their epigenetic profiles.
Patients with systemic infection or gestational diabetes causing severe insulin resistance or patients with genetic and autoimmune defects of insulin action also may benefit from such treatment (31).
These observations are consistent with the function of these genes in mammalian animal models and human patients, where MYD88 and TRAF6 mutations are associated with immunodeficiencies and SHP1 mutations cause inflammatory phenotypes and autoimmune defects.
Apart from the dealing with fasciolosis, synthetic versions of the identified virulence and immunomodulatory genes reported in this study could be important to control undesired pro-inflammatory responses, by considering immunoregulatory effects of the parasite and current therapeutic approaches in the treatment of autoimmune defects (e.g. helminth therapy) [ 70- 73].
The knockout models of spontaneous type 1 diabetes or other autoimmune defects (mice in which one or more genes have been turned off through a gene knockout) may identify a new set(s) of genes/mutations in the development of human type 1 diabetes.
Other possible causes of preeclampsia and eclampsia include genetic defects, autoimmune disorders, and diet.
A variety of nanodrug delivery systems such as nanoemulsions, lipid or polymeric nanoparticles, and liposomes are being investigated as functional drug carriers for treating a wide range of therapies, most notably cardiovascular defects, autoimmune diseases, and cancer.
In various spontaneous autoimmune animal models, defects pertaining to the interaction of APC and thymocytes interferes with the normal process of negative selection.
Disruption of PD-1 in mice results in the development of a lupus-like autoimmune syndrome, and defects in PD-1 have been implicated in a number of other animal models of autoimmunity (Nishimura et al., 1999; Fife et al., 2006; Gianchecchi et al., 2013).
Addison's is presumed to be an autoimmune mediated hereditary defect but the mode of inheritance remains unclear.
