Pancytopenia and autoimmune abnormalities, such as anti-nuclear antibody, rheumatoid factor, and hypocomplementemia, were not detected.
This result suggests that preexisting autoimmune abnormalities indicated by ANAs may influence the effect of IFX.
These reports show that PIG tends to be associated with autoimmune abnormalities, such as systemic lupus erythematosus (SLE).
It has been assumed that a combination of immunologic, genetic, and environmental factors plays an important role in the development of autoimmune abnormalities in primary SS.
However, HCV infection has been reported to predispose patients to extrahepatic disorders involving renal, dermatologic, hematologic, and rheumatologic systems as well as autoimmune abnormalities [ 37- 39].
Moreover, dysregulation of apoptotic pathways can lead to development of pathological conditions in brain such as cancers, ischemic and autoimmune abnormalities, and neurodegenerative disorders, including Alzheimer's and Parkinson's diseases [ 25, 27, 28].
It regulates gene transcription, inhibits cell proliferation, induces apoptosis and plays a role in activating the inflammatory response, including stress-induced inflammation, leading to increases in cardiovascular diseases, autoimmune abnormalities and DM [ 43].
In the current case, however, we did not detect any autoimmune abnormalities or hypocomplementemia by routine laboratory examinations, and there was no glomerular deposition of complement components (C3, C4d, C1q).
Patients with abnormal karyotype, uterine abnormalities, autoimmune conditions, thrombophilia, severe endometriosis, and reduced ovarian reserve were excluded from the study.
