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In this simplified model of vicious cycle, hyperthyroidism leads to worsening of the autoimmune aberration, and autoimmune aberration leads to generation of more TSH receptor antibodies and aggravation of the hyperthyroidism.
Acceptance of the above mechanism on remission highlights the importance of rendering patients euthyroid and maintaining them in that state for a long period to minimize autoimmune aberration and GD recurrence (11).
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Long-term exposure to minocycline has also been associated with a variety of clinical and serological autoimmune aberrations, including serum sickness [16], drug-induced lupus [17], autoimmune hepatitis [18], and vasculitis [19].
Collectively, our data revealed that Radix Astragali effectively protected against cardiac functional and morphological aberrations in experimental autoimmune myocarditis.
Despite the use of sophisticated laboratory tools to uncover the perturbations of immune senescence, a major challenge remaining will be to determine quite how such aberrations translate to autoimmune disease in general, but arthritis in particular.
High content immune profiling in peripheral blood may reflect immune aberrations associated with inflammation in multiple sclerosis (MS) and other autoimmune diseases affecting the central nervous system.
Aberrations at both levels are evident in cancer (34, 35) and autoimmune diseases (36).
Aberrations in the JAK-STAT pathway may be involved in hematopoietic disorders, autoimmune and inflammatory diseases [ 48], and affect susceptibility to infectious diseases [ 47, 49, 50].
Our findings indicate that aberrations at the level of apoptotic microvesicles and possibly DC contribute to the autoimmune response against chromatin in MRL/lpr mice.
Therefore, aberrations of this process may lead to a variety of human pathologies, including cancer, autoimmune diseases, and neurodegenerative disorders.
Aberration in the expression of MMP is associated with a variety of diseases from respiratory to autoimmune disorder and even cancer, particularly lung cancer.
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