The phrase "authentic substrates" is correct and usable in written English.
It can be used in contexts related to biology, chemistry, or materials science, where it refers to genuine or original materials that serve as a base or foundation for a process or reaction.
Example: "In our research, we focused on the effects of authentic substrates on plant growth to ensure accurate results."
Alternatives: "genuine substrates" or "original substrates".
The exact mechanism for the laforin effect on autophagy is still elusive and may remain so for some time pending identification of authentic substrates.
And defiance and persistence paid off as expanded polyglutamines turned out to be excellent substrates for certain TGs, given that they enhanced the reactivity of authentic substrates such as involucrin (Kahlem et al, 1996).
This observation was further strengthened by the fact that only a small proportion (~4 %, i.e., estimated 200 ng) of the yeast tRNAs (5.0 μg) used as a positive control were authentic substrates with 3'- CC for adenylation [ 12], while 100%% of RNA11 (estimated 350 ng to 3.0 μg) should have …CC-3' and therefore be available for 3'-adenylation.
These data suggest that p62 is an authentic substrate of parkin in both cell and animal model systems.
Whether 4E-BP is a direct, authentic substrate of LRRK2 is unclear and should be considered provisional.
Two further results give pause to the conclusion that 4E-BP is an authentic substrate for LRRK2.
In order to account for the possibility that an authentic substrate could actually be in a different compartment, we must know the pattern of distribution of the protease in different compartments, in various tissues and their regulated expression.
However whether 4E-BP is a direct authentic substrate of LRRK2 remains unclear [85].
These are the first liganded structures of a 4HypE and the first structure of a PRS with an authentic substrate.
Taken together, the PP4 complex (containing Pph3) dephosphorylates Maf1 in vitro at rates similar to Rad53, consistent with its identity as an authentic substrate.
Finally, we showed that dishevelled is not an authentic substrate of APC-Cdh1 using both specific ubiquitylation assays and degradation assays in vitro.
