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In vivo, in cardiac-specific CYP2J2 transgenic mice, fasting selectively augments the expression of PDK4.
Besides, NO augments the expression of some specific matrix metalloproteinases [36] which are known to participate in tissue remodeling.
In α1-adrenergic stimulated myocytes, TrpC3 knockdown decreases hypertrophic gene expression while TrpC3 overexpression augments the expression of hypertrophy marker genes.
Our study suggests that TWEAK augments the expression of both NIK (i.e. MAP3K14) and NFkB2 in myotubes (Figure 1B, D, and Table S1).
Furthermore, our microarray data has confirmed our previous findings [71] that TWEAK augments the expression of extracellular protease matrix metalloproteinase-9 (MMP-9) and reduces the levels of MMP-2 and TIMP2 (Figure 1).
We have previously shown that treatment of C2C12 myotubes with TWEAK augments the expression of muscle-specific E3 ubiquitin ligases atrogin and MuRF1 and augments the ubiquitination of select muscle proteins within 12 24h of treatment [20].
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Noman AS et al [ 21] reported that LPS significantly augmented the expression of RIZ1 and the augmentation was mediated by the activation of nuclear factor (NF -κB aNF -κB.
In addition, inhibiting the EphA2 receptor augmented the expression of E- cadherin, which is involved in cell-cell adhesion.
These bone marrow derived macrophages were able to increase their intracellular iron pool that, in turn, augmented the expression of lipocalin-2 and its receptors.
The ACE inhibitors also augmented the expression of HGF in the presence of bradykinin in human aortic endothelial cells in culture (HAECs).
Furtherfore, IL-15 augmented the expression of cytotoxic effector molecules (TRAIL and Perforin) and the phosphorylation of STAT1 and ERK1/2, which may also contribute the NK lysis.
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