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Therefore, it is possible that B [a]P augments repression of genes required for plasma cell differentiation, e.g. XBP-1, by virtue of their expression of Pax5/AhR binding sites.
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To further probe the mechanistic nature of this HIPK3 affect, we examined its ability to augment repression mediated by the known TRβ co-repressor, N-CoR [35], [36], [37].
The unmasking of ORF miREs by PTCs may significantly augment repression by miREs in the 3′ UTR.
In embryonic stem (ES) cells, Brg1 tunes expression of Polycomb target genes resulting in either activation or enhanced silencing, and so may augment repression rather than antagonize it [ 37].
In cells with activated AMPK, CD44-CP1 further augmented the repression of mTOR when compared to vector control (CD44-pcDNA3).
Nevertheless, they also indicate that deadenylation can augment miRNA-mediated translational repression in mammalian cells.
On the other hand they show directly that deadenylation can augment miRNA-mediated translational repression in mammalian cells beyond stimulating mRNA decay.
The insights provided by Chang and colleagues relate to the identification of EZH2 in augmenting BTICs through epigenetic repression of DNA repair, leading to aggressive disease.
The ability to diffuse through the tissues will augment therapeutic effects, and enable repression of blood vessels in the cancer cell proliferating regions.
This landscape suggests that miRNAs, being gene regulatory factors via translational repression, were down-regulated to yield augmented gene expression in response to H1N1 infection.
This suggests that Socs3 repression is a mechanism by which NANOG augments LIF signal transduction in ESCs, resulting in higher levels of active pSTAT3.
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