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High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality.
IL-6 is expressed by monocytes/macrophages, endothelial lineage cells, and fibroblasts and augments immune responses via induction of T cell activation, B cell proliferation and differentiation, and stimulates acute phase protein release (e.g. C-reactive protein) [38].
Other work has indicated that aging augments immune priming by donor DCs [23] and our study does not exclude that aging may play important roles of the function of donor DCs, especially when DCs originate from vascularized allografts.
Published data indicate that psychological stress (in short, stress) breaks the established tolerance in the intestine, 1 2 compromises intestinal epithelial barrier function 3 and augments immune responses.
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Vaccine adjuvants are traditionally defined as chemical compounds or macromolecules that augment immune responses of co-administered antigen (Ag) with minimal toxicity or long lasting immunity on their own.
Non-specific immunostimulants act irrespective of antigenic specificity to augment immune response and stimulate components of the immune system.
In addition, ILC2s may express the antigen-presenting molecule MHCII and can crosstalk directly with Th2 cells to augment immune responses (Oliphant et al., 2014).
Peptides that mimic carbohydrate antigens offer new possibilities to augment immune responses to such antigens that include inducing carbohydrate reactive T-cell responses.
A brief exposure of skin to a low-power, non-tissue damaging laser light has been demonstrated to augment immune responses to intradermal vaccination.
Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections.
The ability to augment immune responses using poxvirus-based vaccines containing multiple costimulatory molecule transgenes can now be addressed in the rhesus macaque model.
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